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Dim diindolylmethane professional#

3,3’-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. 3,3’-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin.

Cell cycle-dependent effects of 3,3’-diindolylmethane on proliferation and apoptosis of prostate cancer cells. Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3’-diindolylmethane in HT-29 human colon cancer cells. Apoptosis-inducing effect of erlotinib is potentiated by 3,3’-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3’ diindolylmethane (DIM). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

Higdon JV, Delage B, Williams DE, Dashwood RH.

Pilot study: effect of 3,3’-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.

Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF.

Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

Howells LM, Moiseeva EP, Neal CP et al.

A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals. More research is needed to elucidate the pharmacokinetics and clinical efficacy of tamoxifen when taken with DIM. However, this increase was coupled with a reduction in metabolites from tamoxifen. In an RCT of estrogen receptor-positive breast cancer patients taking tamoxifen, daily DIM promoted an increase in the metabolite ratio of 2-hydroxyestrone (2-OHE1, anti-tumorigenic) to 16α-hydroxyestrone (16α-OHE1, pro-tumorigenic) (25). One pilot study suggests DIM may lead to changes in estrogen metabolism in postmenopausal women with a history of early stage breast cancer (4). Data suggest daily supplementation with DIM may benefit patients with castration-resistant prostate cancer by inhibiting the androgen receptor (20), but studies are mixed on whether it exerts positive effects in women with cervical cell abnormalities (13) (21). However, studies in humans are quite limited. In vitro and in animal studies suggest DIM has anti-inflammatory (16) (17), antiproliferative (16) and chemopreventive (18) effects, and may also help increase bone mass (19). It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer (3). In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website.ĭiindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage, and cauliflower.

Dim diindolylmethane professional#

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